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PHD Degree in Biochemistry and Molecular Biology

December 23, 2013

For me, the greatest excitement in life is tackling a problem or issue in the life sciences and solving it through the application of scientific principles and techniques. Since I was very young, I have cultivated a single-minded devotion to this field of study in preparation for my career as a scientist, ultimately dedicating my life to saving others lives. I am especially devoted to the battle against cancer and hepatitis. I want very much to pursue a PHD at XXXX because it is the finest program in the world.

 I am especially confident that I am a strong candidate for your program because I have now completed two years of full time research as a Research Technologist at XXU. Throughout this period, I have become a highly competent researcher with exceptional laboratory skills. I began working in the lab of Dr. XXXX, performing several techniques such as ELISA, protein purification etc., primarily measuring the serum antigen and antibody responses of woodchucks in our investigations of this animal model of Hepatitis B infection. Using similar techniques, I also measured antibody responses in mice and rabbits with the goal of achieving successful immunization against woodchuck virus antigens. My experience in Dr. XXXX´s lab has helped me to master self-discipline, focus, concentration, and the patience required to excel in scientific research. I have also had the enormous privilege of working with the research group in the cancer laboratory of Dr. XXXX, investigating the “Effects of Dietary/Nutrition Components on the Programming of Mammary Gland Developments, and its Effects on Breast Cancer Susceptibility.” I find special fulfillment in working towards this cause and mastering the appropriate techniques, such as those involved with Immunohistochemistry, Genotyping, ELISA and the handling of live mice. I have become adept at working as part of a group, and learned the profound importance of the exchange of scientific ideas, questioning, and the communication that is required for cutting-edge research.

Previously, I gained invaluable experience as a Masters student working in several labs at Georgetown University devoted to the study of skin cancer, breast cancer, and Hepatitis B. I did my summer internship at XXXX University under the guidance of Dr. Cynthia Rosenthal, working on “ID3 protein expression in immortalized squamous cells and carcinoma cells, as well as UVB irradiation and its influence on the apoptosis of cells.” I especially enjoyed comparing UVB effects on the  xpression of ID3 in different cell types (primary HFK, malignant & immortalized) as well as the over all effects on tumor progression in vivo by using immune compromised mice for out model system. This experience helped me to become even more comfortable in the laboratory environment and further strengthened my interest in scientific research. Furthermore, I became acquainted with a variety of related areas of research by working as a part time research technician for other laboratories at XXXX.

Before coming to America from my native India, I completed my undergraduate studies at the P.B Siddhartha College in India, which provided me with a strong background in the fundamentals of Biochemistry, Microbiology & Chemistry, and a profound motivation to pursue these fields as a career. Next, I earned my MSc Degree from XXXX University and had the privilege of serving as an intern at some of Indias most prestigious labs such as the IICT and the BARC.  In addition to developing a solid foundation in biochemistry, microbiology, and cell & molecular biology, I also became highly competent in bioprocess and fermentation technology, as well as protein and genetic engineering, research methodologies, bioinformatics, enzyme technology, and biostatistics. I was able to finely hone my sense of teamwork and had the privilege of presenting numerous papers. Throughout the course of my studies in both India and the United States, I have also supplemented the knowledge and research skills that I have gained through coursework and laboratory experience by attending a variety of seminars and symposiums conducted at different venues on different topics.

 When I began my Masters Program at XXXX, I felt that I had been reborn to a much higher level of existence. Indian laboratories cannot afford the state-of-the art equipment and facilities that I have enjoyed at XXU and XXU, adding enormously to my sense of privilege. In this program, in addition to the areas already mentioned, I was able to learn a great deal about intellectual property, regulatory affairs, manufacturing practices, and the entrepreneurial face of biotechnology. Thus, I feel as if my entire adult life has been geared towards preparing me for entering your PHD program and becoming a world class scientist. Upon completing your program, I hope to serve in a postdoctoral position, which will further prepare me for a lifetime of research and perhaps teaching.

 I see myself first and foremost as a soldier in the battle of life against death. Cancer consumes me because it is consuming my species. I will not rest until I draw my final breath. I thank you for consideration of my application to your program.

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